Drug resistance and antiretroviral drug development
نویسندگان
چکیده
منابع مشابه
Drug resistance and antiretroviral drug development.
As more drugs for treating HIV have become available, drug resistance profiles within antiretroviral drug classes have become increasingly important for researchers developing new drugs and for clinicians integrating new drugs into their clinical practice. In vitro passage experiments and comprehensive phenotypic susceptibility testing are used for the pre-clinical evaluation of drug resistance...
متن کاملAntiretroviral Drug Resistance and Routine Therapy, Cameroon
Among 128 patients routinely receiving highly active antiretroviral therapy in an HIV/AIDS outpatient clinic in Cameroon, 16.4% had drug resistance after a median of 10 months. Of these, 12.5% had resistance to nucleoside reverse transcriptase inhibitors (NRTIs), 10.2% to non-NRTIs, and 2.3% to protease inhibitors.
متن کاملDrug Resistance
عفونت و تهاجم ارگانیسم های انگلی به بدن، عامل اصلی بیماری و مرگ انسانها از آغاز بشریت بوده است . در حقیقت بسیاری از اشکال حیات بدون غلبه بر ارگانیسم های زنده دیگر، قادر به ادامه زندگی نخواهند بود. انسانها معمولا مستعد تهاجم ارگانیسم های کوچکتری مانند کرمها، آمیب ها، قارچها، باکتریها و ویروسها هستند. این عوامل مکان خاصی را در بدن انتخاب کرده، مواد ضروری لازم برای حیات و تکثیر خود را دریافت نموده...
متن کاملDrug- Resistance- Associated Mutations and HIV Sub-Type Determination in Drug-Naïve and HIV-Positive Patients under Treatment with Antiretroviral Drugs
Abstract Background and Objective: Resistance to antiretroviral agents is a significant concern in clinical management of HIV-infected individuals. Resistance is the result of mutations that develops in the viral protein targeted by antiretroviral agents. Material and Methods: In this cross-sectional study, the blood samples of 40 HIV-positive patients were collected. Twenty of them were d...
متن کاملTherapeutic drug monitoring and drug-drug interactions involving antiretroviral drugs.
The consensus of current international guidelines for the treatment of HIV infection is that data on therapeutic drug monitoring (TDM) of non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (Pls) provide a framework for the implementation of TDM in certain defined scenarios in clinical practice. However, the utility of TDM is considered to be on an individual basis ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2005
ISSN: 1460-2091,0305-7453
DOI: 10.1093/jac/dki127